Myo-inositol is a type of sugar alcohol that plays important roles in cell signaling, insulin sensitivity, and various metabolic processes.
It plays a central role in glucose metabolism, insulin sensitivity, reproductive hormone regulation, and cellular signal transduction.
Myo-inositol is a naturally occurring carbocyclic sugar alcohol (polyol) and the most abundant of the nine inositol isomers in humans.
It is present in most tissues, synthesized endogenously, mainly by the kidneys-up to 4 g daily.
It found naturally in foods like fruits, beans, grains, and nuts.
It is present in most human tissues and is involved in multiple metabolic processes, including this insulin signaling pathway.
Supplementation improves insulin sensitivity, metabolic profiles, and natural conception rates in individuals with PCOS.
People often take myo-inositol supplements for PCOS (Polycystic Ovary Syndrome).
It potentially helps with insulin resistance, ovulation, and hormonal balance in PCOS, may improve egg quality and hormonal function.
Sometimes used for anxiety, depression, and OCD
Can help with insulin sensitivity and blood sugar regulation
Common doses range from 2-4 grams daily, though some conditions (like PCOS) may use higher doses.
It’s often combined with d-chiro-inositol in a specific ratio (40:1).
Generally well-tolerated with mild side effects if any (like nausea or digestive upset at high doses).
Myo-inositol is a key component of cell membrane phospholipids and serves as a precursor for second messengers involved in numerous cellular signaling pathways, including insulin, FSH, and TSH signaling.
Myo-inositol is a vital molecule for metabolic and reproductive health, with established therapeutic roles in endocrine and metabolic disorders, especially those involving insulin resistance and ovarian dysfunction.
In a randomized trial, myo-inositol supplementation during pregnancy did not reduce the incidence of a composite of gestational diabetes, preeclampsia, or pre-termbirth in patients with PCOS (van der Wel, A).