See ((Kidney function))
Creatinine clearance (CCr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
Creatinine based eGFR is currently the standard method of estimating GFR because it’s widely available, cost-effective, and familiar.
Serum creatinine levels depend in part on muscle mass, creating variability across age, sex, and nutritional status.
Creatinine undergoes, variable tubular secretion, which is influenced by medication such as cemetidine and trimethoprim, declining kidney function, and individual physiology, which can compromise eGFRcr accuracy.
Patients with a creatinine clearance of less than 36.9 cc/min have a 2 fold increase greater risk in developing CHF compared to patients with a Creatinine clearance of >57 cc/min.
Creatinine clearance exceeds GFR due to creatinine secretion.
Both GFR and CCr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result (eGFR and eCCr)