Creatine kinase (CK)

Also known as phosphocreatine kinase or CPK.

An enzyme present in muscle, brain, and other tissues that catalyzes the reversible conversion of ADP and phosphocreatine into ATP and creatine.

In tissues that consume ATP rapidly as skeletal muscle, brain, smooth muscle, retina photoreceptor cells, and spermatozoa it serves as an energy reservoir for rapid regeneration of ATP.

Thoracotomy may result in substantial release of CK from skeletal muscle, which contains 1-3% of CK-MB.

Elevation in skeletal muscle CK value may be seen in polymyositis, statin-induced myopathy, muscular dystrophy, and rhabdomyoma lysis.

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