Creatinine clearance

See ((Kidney function))


Creatinine clearance (CCr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. 

Patients with a creatinine clearance of less than 36.9 cc/min have a 2 fold increase greater risk in developing CHF compared to patients with a Creatinine clearance of >57 cc/min.

24 hour urine creatinine is estimated to be 15 mg per kilogram per deciliter in females and 20 mg per kilogram per day in males.

Creatinine clearance exceeds GFR due to creatinine secretion.


Both GFR and CCr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result (eGFR and eCCr) 

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