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Crest syndrome

Calcinosis cutis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia.

70-90% of patients with this syndrome have anti-centromere antibodies.

A variant of 2242with chronic edema of the hands, which leads to sclerodactyly and reabsorption of the bony tufts on distal digits.

In patients with diffuse disease visceral involvement, poor prognosis and higher mortality are present.

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