Vonoprazan (Voquezna)

Vonoprazan an oral proton pump inhibitor

Tradename Voquezna

Voquezna is an oral potassium-competitive, acid blocker that may be used to block acid production in the stomach and is approved for the:

Relief and maintenance treatment of heartburn associated with erosive esophagitis.

Relief of, and to maintain healing of, all grades of erosive esophagitis.

Treatment of Helicobacter pylori (H. pylori) infection in adults in combination with amoxicillin and clarithromycin or amoxicillin.

Voquezna works by inhibiting the potassium-dependant component of the H+, K+-ATPase enzyme system (the acid proton pump) within the parietal cell, blocking the final step of acid production.

Voquezna does not require acid to activate it, concentrates in parietal cells, and binds reversibly and non-covalently to the pump.

It suppresses both basal and stimulated gastric acid secretion.

Certain medications that are used to treat HIV-1 may interact with Voquezna and they should not be used together.

May cause acute tubulointerstitial nephritis, a type of acute kidney injury.

May increase the risk of Clostridioides difficile-Associated Diarrhea (CDAD) and increase the risk of osteoporosis-related fractures.

It should be taken for the shortest duration appropriate to the condition.

It is associated with an increased risk of severe skin conditions including severe cutaneous adverse reactions.

Long-term use may lead to malabsorption or deficiency of Vitamin B12, low magnesium levels, or fundic gland polyps.

It is not known if Voquezna will harm an unborn baby, or if it passes into breast milk.

Voquezna may cause serious side effects, including:

Acute tubulointerstitial nephritis).

Diarrhea, caused by an infection Clostridioides difficile.

Bone fractures

Severe skin reactions.

Lower Vitamin B-12 levels by lowering the amount of acid in your stomach and stomach acid is needed to absorb Vitamin B12 properly.

Lowers magnesium levels.

Increases the risk of fundic gland polyps.

The most common side effects of Voquezna when used for erosive esophagitis affecting 2% to 3% or more people include:

diarrhea high blood pressure indigestion nausea stomach bloating stomach inflammation stomach pain urinary tract infection.

The most common side effects of Voquezna when used with antibiotics for treatment of H. pylori infection affecting 2% or more people include:

cold-like symptoms diarrhea headache high blood pressure stomach pain temporary changes in sense of taste vaginal yeast infection.

Voquezna may affect how other medicines work and other medicines may affect how it works.

atazanavir digoxin or other drugs that cause hypomagnesemia nelfinavir medicines that contain rilpivirine used to treat HIV-1 (Human Immunodeficiency Virus) other antiretrovirals or medicines (such as iron, or ketoconazole) dependent on gastric pH for absorption certain CYP3A substrates with a narrow therapeutic index, such as theophylline CYP2C19 substrates, such as clopidogrel, or citalopram.

It interfere with investigations for gastrinoma or neuroendocrine tumors. Altering assessment of chromogranin A (CgA) levels or performing a secretin stimulation test.


Leave a Reply

Your email address will not be published. Required fields are marked *