Subacute cutaneous lupus erythematosus


A rash that typically affects white women age 30-40 years.

A non–indurated, non-scarring, erythematous plaques with or without a fine scale that may progress into a diffuse, widespread, papulosquamous or annular lesion with central hypopigmentation all telangiectasia (Sontheimer RD et al).

Usually appears on sun exposed areas.

Spares the knuckles and face.

Associated with other rheumatological diseases such as rheumatoid arthritis and Sjogren’s syndrome and medication such as hydrochlorothiazide.

Process may be exacerbated by photosensitizing drugs.

Clinically worse during spring and summer.

Differential diagnosis includes drug exanthema, scabies, psoriasis, and paraneoplastic syndromes.

Managed by sun protection and avoidance.

Topical therapy with corticosteroids and antimalarial agents may be useful.

In refractory patients mycophenolate sodium is beneficial.

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