Spermidine is a naturally occurring polyamine compound found ubiquitously in living cells.
Itplays essential roles in cellular growth, proliferation, and homeostasis.
Spermidine is synthesized from putrescine and serves as a precursor to spermine.
Spermidine is involved in critical biological processes such as nucleic acid and protein synthesis, regulation of ion channels, and protection against oxidative stress.
It is also required for the post-translational modification essential for the translation of specific mRNAs.
Spermidine levels decline with age, and studies suggest that increased dietary intake or supplementation of spermidine is associated with improved healthspan, reduced cardiovascular and cancer-related mortality, and potential neuroprotective effects.
Spermidine is recognized as a potent inducer of autophagy, a cellular recycling process implicated in longevity and protection against age-related diseases.
It is abundant in various foods, including wheat germ, soybeans, mushrooms, and some aged cheeses.
Clinical guidelines for its supplementation or therapeutic use have not yet been established.