Risedronate (Atelvia)

Oral bisphosphonate for postmenopausal osteoporosis.

Weekly oral treatment that can be administered immediately after food intake.

It slows down the cells which break down bone.

It is used to treat or prevent osteoporosis, and treat Paget’s disease of bone.

It is taken by mouth.

Trade names Actonel, Atelvia,

Pregnancy category AU: B3

Routes of administration By mouth



Protein binding


Metabolism None

Elimination half-life 1.5 h


Kidney and fecal

Bisphosphonate Relative potency

Etidronate 1

Tiludronate 10

Pamidronate 100

Alendronate 100-500

Ibandronate 500-1000

Risedronate 1000

Zoledronate 5000

In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the jaw, often preceded by dental procedures inducing trauma to the bone.

A safe and effective drug in preventing bone mineral density loss in patients with both breast and prostate cancer.

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