Rabeprazole (Aciphex)

Oral proton pump inhibitor.

Has a bioavailability of 52%.

Metabolism and is mostly non-enzymatic, with partial hepatic (CYP2C19) and a 1-1.5 hour half-life.

Excretion is 90% renal.

Short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease.

Reeducing relapse rates of heartburn symptoms in patients with GERD.

Can bw utilized for the long-term treatment of hypersecretory conditions, including Zollinger-Ellison syndrome.

Utilized in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.

Dosage of 20 mg tablets daily.

Side effects include headache in 2.4% of patients.

Side effects include: diarrhea, nausea, vomiting, abdominal pain, constipation, decreased appetite, dry mouth, asthenia, anxiety, insomnia, pancytopenias, rash, myalgias, and arthralgia.

May decrease the concentration of ketoconazole and increases the concentration of digoxin, and does not interact with liquid antacids.

Compatible with any medicine metabolized by the CYP450 which includes theophylline, warfarin, diazepam, and phenytoin.

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