Postsplenectomy syndrome

The spelled contains nearly half of B lymphocytes producing immunoglobulins, and essential for production of opsonizing antibodies.

Opsonization is critical for clearance of encapsulated organisms.

Patients with asplenia at risk for postsplenectomy sepsis, a fulminant and often fatal process caused by infections normally cleared from the circulation by the spleen.

Encapsulated organisms are the most common causes of sepsis in asplenic patients, and include: Streptococcus pneumoniae, H. Influenza, and Neeisseria meningitis.

More than 50% of the cases of sepsis related to S. pneumoniae.

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