Plasma cell


Function is the synthesis and excretion of immunoglobulins.

Found in the bone marrow, and are not normally found in the circulation.

Normally does not exceed 2% concentration in the bone marrow.

Arise at the end-stage of B cell differentiation and to a large activated plasma cell.

When B cell lymphocytes undergo antigenic stimulation and blast transformation plasma cells are formed.

Following antigen exposure of a viral or bacterial infections, naïve B cells normally proliferate and undergo somatic hypermutation of the IgH and IgL sequences producing long lived plasma cells.

When B cell lymphocytes encounter an antigen that binds immunoglobulin surface receptors and receive a second signal provided by helper T cells allows blast cell transformation and proliferation of a mature plasma cell.

After blast self transformation to a mature B cell with a size of 18 to 20 µm, has an eccentrically placed nucleus, fine chromatin and blue nongranular cytoplasm.

Plasmacytoid lymphocytes have an overall size of 15-25 microm, eccentrically placed nucleus, dark blue cytoplasm, and a lighter stained are, the hof,next to the nucleus.

The hof represents the golgi apparatus.

Mature plasma cells are 14-20 microm, small eccentrically placed nucleus, with condensed chromatin with a cartwheel configuration.

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