Pentaglobin is an IgM-enriched intravenous immunoglobulin preparation.
Pentaglobin is a polyclonal immunoglobulin preparation comprised of immunoglobulin G (IgG) and immunoglobulin A (IgA), enriched with immunoglobulin M (IgM). 
Each ml contains 50 mg of human plasma protein (at least 95% immunoglobulin), with IgM 6 mg, IgA 6 mg, and IgG 38 mg.
It is prepared from pooled material from not fewer than 1,000 donors. 
Mechanism of action: The IgM in the preparation plays a role in complement activation and neutralization of bacterial endo- and exotoxins.
Pentaglobin is used as an adjuvant in the treatment of severe bacterial infections and is also being investigated against peritonitis, sepsis, and COVID-19. 
It is used to treat immunoglobulin deficiency and inflammatory disorders including primary immune thrombocytopenia, Guillain-Barré syndrome, Kawasaki disease, chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy. 
Administration: Pentaglobin is given by intravenous infusion. In neonates and infants the rate is 1.7 ml/kg/hour; in children and adults, 0.4 ml/kg/hour. It should be warmed to at least room temperature before administration and stored at +2°C to +8°C. 
It may cause injection site reactions, headache, fever, flu-like symptoms, and throat tightness. 
It can also reduce the efficiency of some live vaccines such as measles/mumps/rubella or chickenpox vaccines.