Pancreatic enzyme supplementation

With pancreatic insufficiency exogenous pancreatic enzyme supplementation or a low fat free are the treatments.

Effectively reverses, but does not completely abolish, steatorrhea.

With uncoated enzymes, gastricacid suppression may be necessary to prevent inactivation of tf lipase.

Enteric coated enzymes utilized to prevent inactivation of lipase.

Lipase in enteric coated delivery system requires a luminal pH of greater than 5.0.

Indicated for the treatment of pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatic cancer and post-pancreatectomy.

Bicarbonate buffering creates optimal pH environment to increase lipase activity (Pertzye).

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