Complexes if DNA and histone proteins and are the main form of cell free CNA in blood.

Higher levels in cncer patients compared to helathy contol.

Elevated levels may be seen in benign diseases. limiting ability for levels to be a tumor diagnosistic marker.

Apoptosis is a major source of nucleosome release into the circulation.

Most cytotoxic treatment cause apoptotic cell death and release of nucleosomes.

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