Nuclear factor-κ (NF-κB )

A transcription factor in B cell nucleus that binds to enhancer of the kappa chain of immunoglobulin and is expressed in cytoplasm of all types of cells.

A transcription factor activated by the EGFR pathway.

Translocates into the nucleus when activated and it helps regulate more than 200 genes that control inflammation and cellular growth.

Plays important role in inflammation, immunity, cellular proliferation and apoptosis.

Activity regulated by nuclear to cytoplasm shuttling mechanisms mediated by signaling cascades.

Ab2242ant activation of NF-kB seen in glioblastoma.

NK-kB inhibitor alpha (NFKBIA) represses NF-kB and therefore signaling in the NF-kB and EGFR pathways.

NFKBIA is often deleted but not mutated in glioblastomas.

Deletion of NFKBIA has the effect of amplification of EGFR in the pathogenesis of glioblastoma, and is associated with a short survival.

NFKBIA is a tumor suppressor and mutations are associated with Hodgkin’s disease, myeloma, hepatocellular carcinoma, and breast cancer.

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