Natriuretic peptides

Key regulators of metabolic processes, including activation of lipolysis, lipid oxidation and mitochondrial respiration.

Function as mediators in cardiac-adipose tissue network, helping to ensure adequate supply of fuel for normal myocardial function.

The cardiac natriuretic peptide hormone system, comprises two main peptides – atrial natriuretic peptide (ANP) & B-typenatriuretic peptide (BNP), also known as brain naturopathic peptide.

ANP and BNP are secreted from atrial and ventricular cardiomyocytes, respectively, in response to varying stimuli.

Both peptides bind the receptors in the kidney and blood vessels and promote natruresis, diuresis, and vasodilatation.

These peptides, indirectly regulate apical cell surface, epithelial sodium channels in the kidney, which are composed of three subunits and lead to cyclic guanosine monophosphate reduced epithelial sodium channel inhibition, and hampering of sodium reabsorption.

Natriuretic peptides are synthesizes as pre-pro hormones, which undergo cleavage to form pro hormones.

proteolytic removal of the N- terminal pro-natriuretic peptide (NT-proNP), converts proANP and proBNP to their active forms.

Has a role in regulating metabolism and energy expenditure.

Members of the cardiac endocrine system that regulates the fullness of the circulation.

Associated with natriuresis with the response localized to electron dense secretory granules in the atria containing atrial natriuetic peptide (ANP).

Atrial distention due to volume expansion with saline, water immersion, postural changes, and salt intake resulting in an increased plasma atrial natriuretic peptide.

Circulating ANP and BNP act on the kidney to promote diuresis and natriuresis and exert vasodilatation on peripheral capacitance vessels.

Release of NP are both a sensing and an effector mechanism when low blood pressure atria and high pressure ventricle guard against adverse affects of intravascular volume expansion by stimulating excretion of the extracellular fluid volume and dampening the rise of mean arterial pressure.

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