Includes methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), carbapenem resistant acinetobacter and Pseudo areuginosa infections.
These organisms have become endemic in many acute-care and long-term care health facilities.
Infections with these organisms are difficult to treat due to a decreasing armamentarium in active antimicrobial agents.
Incidence of several MDR pathogens has decreased: MRSA, VRE, carbapenem resistant acinetobacter and Pseudo areuginosa infections.
The incidence of extended spectrum beta-lactamase producing enterobactericeae significantly increased recently.
The combination of bedaquiline, preomanid, and linezolid Led to a favorable outcome at six months after the end of therapy in a high percentage of patients with highly drug resistant forms of tuberculosis (Conradie F).