Agentbused for prophylaxis of migraine headaches and is sold under the brand names Sansert and Deseril in 2 mg dosages.

Interacts with serotonin (5-HT) receptors.

Clinical effect in migraine prophylaxis has been associated with its antagonism at the 5-HT2B receptor.

It is also an antagonist at the 5-HT2C receptor, and a partial agonist at the 5-HT1A receptor

Metabolized into methylergometrine, which is responsible for its psychedelic effects.

Used to treat migraine and other recurrent throbbing headaches.

One of the most effective agents for the prevention of migraine.

Does not treat of an acute migraine attacks.

Used in carcinoid syndrome to treat diarrhea.

Retroperitoneal fibrosis can occur.

Rarely can cause pleural fibrosis, subendocardial fibrosis and increased risk of left-sided cardiac valve disease.

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