Metronomic chemotherapy

Refers to treatment of chemotherapy at regular, close intervals without prolonged breaks at doses significantly less than the maximum tolerated dose (Kerbel RS).

It is intended to provide sustained anti-angiogenesis by preventing vascular endothelial cell proliferation (Hirata S).

It may induce endogenous inhibitor is an angiogenesis such as thrombospondin-1(Bocci G).

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