Malignancy in pregnancy

Estimated occurrence of one per 1000.

Most common are breast, cervix, lung, melanoma, lymphoma and leukemia, in decreasing order.

Leukemia in pregnancy incidence 1 in 75,000.

Acute myelogenous leukemia accounts for more than two-thirds of cases of leukemia in pregnancy and the diagnosis is usually made in the second and third trimesters.

Successful management of acute leukemia in pregnancy is possible.

Chemotherapy appears to be increasingly safe as pregnancy approaches term.

Occult malignancy in pregnancy can be diagnosed with noninvasive prenatal testing when it shows discordance with fetal karyotype.

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