Refers to an increase in the number of blood leukocytes.

Common reaction to inflammatin and may be an indication of neoplastic involvement of leukocytes.

Its presents often triggers administration a broad-spectrum empiric antibiotics especially when clinical symptoms were history suggest infection.

Leukocytosis, especially with early myeloid forms is considered a strong sign for microbial sepsis as well as other inflammatory states.

The peripheral blood count reflects the size of the myeloid and lymphoid precursors, the size of storage pool cells in the bone marrow, circulation and peripheral tissues.

The peripheral blood count is influenced by the rate of release of cells from the storage pool into the circulation.

The peripheral white blood cell count varies with the proportion of cells that adhere to the blood vessel wall.

The peripheral white blood cell count is reflective, also, on the rate of extravasation of such cells from the blood into the tissues.

Leukocyte homeostasis maintained by growth factors, cytolines and adhesion molecules effecting cell commitment, proliferation, differentiation and extravasation.

Leukocyte homeostasis related to cytokines, growth factors and adhesion molecules altering stem cell commitment, proliferation, differentiation and extravasation.

In acute infection gametocytes rapidly eggress from the bone marrow, which is approximately 50 times the size of the peripheral marginal pool.

Il-1, TNF, and other cytokines from inflammatory changes stimulate bone marrow stromal cells and T cells to produce increased levels of colony stimulating factors that cause white blood cell proliferation and differentiation of committed granulocytes.

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