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K-ras

Most frequent mutated protooncogene in colorectal cancer.

Encodes a plasma membrane bound protein involved in G-protein mediated signal transduction.

Controls growth and differentiation by transduction of extracellular signals.

Belongs to the RAS family of cellular protooncogenes.

RAS viral oncogene homolog NRAS predicts for resistance to cetuximab and panitumumab in colorectal carcinoma.

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