A NSAID that inhibits prostaglandin synthesis and reversibly binds to cyclooxygenase.
Functions as a tocolytic drug by inhibiting prostaglandin production.
Inhibits production of thromboxane production and prolongs the bleeding time.
Renal effects include fluid retention, oliguria, hyperkalemia or anuria.
In extremely low-birth-weight infants prophylaxis with indomethacin reduces the frequency of patent ductus arteriosus and severe periventricular and intraventricular hemorrhage.
Approximately 20 infants must receive indomethacin prophylaxis to avert one operation for closure of the ductus arteriosus.
Rectal indomethacin in patients at high-risk of for post-ERCP pancreatitis significantly reduces the process, 9.2% vs. 16.9% in the placebo group (Elmunzer BJ et al).