In 2003 National Survey on Drug Use and Health reported 3.7 million people in the U.S. used heroin at some point in their lives.

1.2% of 10-12th graders in 2004 reported ever using heroin.

Most commonly associated with opioid dependence.

Diacetylmorphine, the active ingredient in heroin.

Use of injectable diacetylmorphine in dependent patients more likely to keep patients in treatment and reduces the use of illegal drugs and other illegal activities than patients assigned to methadone (Oviedo-Joekes).

Overdose and seizures are the two most common serious adverse events related to diacetylmorphine.

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