Froin’s syndrome is the coexistence of xanthochromia, high protein level and marked coagulation of cerebrospinal fluid (CSF).
It is caused by meningeal irritation and CSF flow blockage by tumor mass or abscess.
Stagnation of the CSF within the thecal sac facilitates exudation from the tumor itself and activation of coagulation factors.
A magnetic resonance imaging is used for identification of CSF flow obstruction.
It often shows the prolongation of T1 and T2 signal in CSF caudal to a level of block.
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