GATA4 is a transcription factor that plays a critical role in the development and function of various organs, prominently the heart and digestive systems.

GATA4 located on chromosome 8.

The GATA family of transcription factors is involved in regulating gene expression during embryonic development and tissue differentiation.

GATA4 is primarily known for its role in cardiac development

GATA4 is essential for the formation and function of the heart. 

It regulates the expression of genes involved in cardiac muscle differentiation, contraction, and remodeling. 

Mutations in the GATA4 gene have been associated with various congenital heart defects, including atrial septal defects and ventricular septal defects.

GATA4 is also involved in the development and function of other organs, such as the gastrointestinal tract, pancreas, and liver. 

It regulates the expression of genes involved in intestinal development, pancreatic beta-cell function, and hepatic metabolism.

GATA4 is a crucial transcription factor that plays a vital role in the development and function of multiple organs, particularly the heart and digestive system.

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.

It is a member of the GATA family of zinc finger transcription factors. 

This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. 

Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects.

GATA4 is a critical transcription factor for proper mammalian cardiac development and essential for survival of the embryo. 

GATA4 works in combination with other essential cardiac transcription factors.

 It is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also regulates hypertrophic growth of the heart.

GATA4 promotes cardiac morphogenesis, cardiomyocytes survival, and maintains cardiac function in the adult heart.

Mutations or defects in the GATA4 gene can lead to congenital heart disease, abnormal ventral folding, and defects in the cardiac septum separating the atria and ventricles, and hypoplasia of the ventricular myocardium.

It is essential for cardiac formation and the survival of the embryo during fetal development.

GATA4 is important for cardiac development, the development and function of the mammalian fetal ovary and contributes to fetal male gonadal development and mutations may lead to defects in reproductive development. 

GATA4 has an integral role in controlling the early stages of pancreatic and hepatic development.

It is regulated through the autophagy-lysosome pathway in eukaryotic cells. 

In cellular senescence, Inhibition of p62 an autophagy adaptor isresponsible for selective autophagy of GATA4. 

Inhibition of p62 leads to increased GATA4 levels, resulting in NF-kB activation and subsequent SASP induction.

GATA4 expression during cardiac development is essential to proper atrioventricular (AV) formation and function.

Endocardial cells undergo epithelial to mesenchymal transitions (EMT) into the AV cushions and septum formation during development influenced by GATA4.

Mutations in this gene have been associated to cases of congenital diaphragmatic hernia.

Atrial septal defects, tetralogy of Fallot, and ventricular septal defects associated with GATA4 mutation  have been identified.

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