The most common extranodal lymphoma and accounts for about 30% of all primary extranodal lymphomas.
About half are of gastric origin and 30-40% occur in the small bowel.
Most are of B-cell lineage, with diffuse, large B-cell lymphoma being the most common histology.
In the middle east and Medit
H. Pylori infection may contribute to lymphoma involving the mucosa-associated lymphoid tissue of the stomach.
Other small bowel lymphomas include enteropathy associated T-cell lymphoma associated with celiac disease, Burkitt’s lymphoma, and B cell lymphomas.
Most the GI lymphomas are associated with obstruction, perforation, or hemorrhage.