Freeze dried sterile human plasma fraction with Factor VIII bypassing activity.
Indicated for the control of bleeding episodes or for surgical treatment in hemophilia A or B patients with inhibitors.
Can be used in patients with acquired inhibitors to factors VIII, XI or XII.
The only aPCC available is FEIBA, a plasma-derived concentrate containing activated clotting factors that has undergone a single-viral inactivation with dry heat vapor treatment.
Overall complete response rate of 86% with a dosing regimen of FEIBA at 75 units/kg every 8–12 hours with a median number of 10 doses to control a severe bleed.
A maximum dose of 200 units/kg within a 24-hour period should not be exceeded, due to a risk of thromboembolism.
Prophylaxis with anti-inhibitor coagulant complex, FEIBA, decreases the frequency of joint and other bleeding events in patients with severe hemophilia A and factor VIII inhibitors (Leissinger C et al).