Eruptive xanthomas

Lipid deposits in the skin which generally indicate hypertriglyceridemia.

Causes include familial hyperproteinemia phenotypes I, IV, V, uncontrolled diabetes, hypothyroidism, alcohol abuse and adverse reactions to medications.

Skin lesions often start when triglyceride levels are greater than 1000 mg/dL.

Skin lesions may be tender or pruritic and may appear as sudden onset of crops of red-yellow papules with erythematosus halo.

Lesions commonly on extensor surfaces of extremities and buttocks.

Lesions contain lipids and lymphocytic infiltrate.

All patients should have lipid profile analysis.

May spontaneously resolve.

Often requires antilipid treatment including diet or pharmacological therapy, or both.

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