Reddened and scaling skin which may be present in psoriasis, atopic dermatitis, cutaneous T-cell lymphoma, drug reactions, and primary blistering disorders.

The differential diagnosis of generalized erythroderma with fever includes: a hypersensitivity drug reaction, inflammatory dermatosis, bullies skin diseases, connective tissue disorders, infections, and malignancies.
Etiology unclear in 25% of cases.

Complications include edema, dehydration, electrolyte abnormalities, hypoalbuminemia, cachexia and alopecia.

Drug hypersensitivity reactions have a spectrum of symptoms that range from skin irruption‘s to life-threatening disorders such as drug reaction with eosinophilia and systemic DRESS syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis.

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