Duloxetine (Cymbalta)

For the treatment of major depression.

A reuptake inhibitor of both serotonin and norepinephrine in the CNS, increasing the activity of these neurotransmitters.

Reduces the perception of pain by modulating pain signals.

Adverse effects include nausea, dry mouth, constipation, dizziness and insomnia

In a randomized, double-blind, placebo controlled crossover trial among patients with painful chemotherapy induced peripheral neuropathy the use of duloxetine compared with placebo forbfive weeks resulted in a greater reduction in pain (Lavoie Smith EM et al).

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