Dornase alfa (Pulmozyme)

A sterile, clear, colorless, highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.

Administered by inhalation of an aerosol mist produced by a compressed air driven nebulizer system.

Daily administration in conjunction with standard therapies is indicated in the management of cystic fibrosis patients to improve pulmonary function.

In patients with an FVC >40% of predicted, daily administration reduces the risk of respiratory tract infections.

Patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.

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