Contain 2 substances that can prevent Escherichia coli from adhering to uroepithelial cells.
Cranberry juice and cranberry products may reduce the recurrence rate of UTIs in women.
Inhibit P-fimbriated uropathological strains of E. coli from uroepithelial cells.
Preventative effect in preventing UTIs by acidification has been refuted (Guay DR).
In a study of 176 premenopausal women with a history of UTI were randomized to cranberry juice vs. placebo:cumulative rate of UTI in the cranberry juice group was 0.29 and 0.37 in the placebo group, with a hazard ratio for UTI of 0.68 compared with placebo, but it was not statistically significant (Stapleton AE et al).
Meta-analysis supports concept that cranberry containing products may protect against UTIs in certain populations: women with recurrent UkTIs, females, children, cranberry juice drinkers and people using cranberry containing reduces more than twice daily (Wang C-H et al).
Long-term tolerance is also an issue with gastrointestinal upset occurring in more than 30% of people on cranberry juice.