Cyclooxygenase 1 (COX-1),is an enzyme that in humans is encoded by the PTGS1 gene.

In humans it is one of two cyclooxygenases.

Chromosome 9 

Isoform is found in platelets and vascular smooth muscle.

Mediates production of thromboxane A2 a promoter of vascular constriction and platelet aggregation.

Plays a role in tissue homeostasis by modulating cell proliferation, angiognesis, and platelet aggregation by thromboxane production.

Prostaglandins are produced following the sequential oxygenation of arachidonic acid, docosahexaenoic or eicosapentaenoic by cyclooxygenases (COX-1 and COX-2) and terminal prostaglandin synthases.


COX-1 is responsible for the baseline levels of prostaglandins.


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