A protein that is found on the surface of many cells.that inhibits circulating macrophages from attacking these cells.
CD47 protein protects cells that should be protected and help dispose of cells that are aged or diseased.
Red blood cells have a lot of CD47 on their cell surface when young but slowly lose it as they age.
When the amount of CD47 on the surface of an aging red blood cells is inadequate the macrophages destroy the aged cells.
Most cancer cells have large amounts of CD 47 on their cell surfaces protecting such cells from the immune system.
CD47 protein can be blocked by anti-CD47 antibodies, enhancing cancer immunity.