Chromosome 17

Contains genes for HER2 and topoisomerase2a as well as other genes implicated in breast cancer.

Second most gene dense chromosome.

Contains breast cancer genes BRAC1 and p53.

20-30% of breast cancers exhibit chromosome 17 polysomy and that suggests that 70 to 80% of women who are treated with an anthracycline in adjuvant fashion derive little or no benefit from it.

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