Charlson comorbidity index

NCI Comorbidity Index

The Charlson Comorbidity Index is a weighted index to predict risk of death within 1 year of hospitalization for patients with specific comorbid conditions.

Each condition is assigned a weight from 1 to 6, based on the estimated 1-year mortality hazard ratio from a Cox proportional hazards model.

Charlson Comorbidity Index (CCI) Predicts 10-year survival in patients with multiple comorbidities.

Scores at Age

<50 years0

50–59 years+1

60–69 years+2

70–79 years+3

≥80 years+4

Myocardial infarction

History of definite or probable MI aged on EKG changes and/or enzyme changes

No 0 Yes+1

CHF Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents No 0 Yes+1

Peripheral vascular disease Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm) No0 Yes+1

CVA or TIA No0 Yes+1

Dementia Chronic cognitive deficit No0 Yes+1

COPD No0 Yes+1

Connective tissue disease No0 Yes+1

Peptic ulcer disease Any history of treatment for ulcer disease or history of ulcer bleeding No0 Yes+1

Liver disease Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension) None0 Mild+1 Moderate to severe+3

Diabetes mellitus None or diet-controlled0 Uncomplicated+1 End-organ damage+2

Hemiplegia No0 Yes+2

Moderate to severe CKD Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L) No0 Yes+2

Solid tumor None0 Localized+2 Metastatic+6

Leukemia No0 Yes+2

Lymphoma No0 Yes+2

AIDS No0 Yes+6

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