CDX-2 is a homeobox protein that in humans is encoded by the CDX2 gene.

This gene is a member of the caudal-related homeobox transcription factor family that is expressed in the nuclei of intestinal epithelial cells.

Gene location-Chromosome 13.

Band 13q12.2

Ectopic expression of CDX2 is present in more than 85% of the human patients with acute myeloid leukemia (AML).

Implicated in the pathogenesis of Barrett’s esophagus where it has been shown that components from gastroesophageal reflux such as bile acids are able to induce the expression of an intestinal differentiation program through up-regulation of NF-κB and CDX2.

A biomarker for intestinal cancer Used in diagnostic surgical pathology as a marker for gastrointestinal differentiation, especially colorectal tissue.

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