A fixed dose combination of estradiol and progesterone, approved for the oral treatment of moderate to severe vasomotor symptoms due to menopause in women with an intact uterus.

Systemic estrogen by oral, vaginal, or trans dermal administration is the most effective treatment for menopausal vasomotor symptoms, reducing hot flashes by 50-100% within four weeks.

Women with an intact uterus to take systemic estrogen should also take a progesterone to reduce the risk of endometrial hyperplasia and adenocarcinoma.

Capsules containing 1 mg of estradiol and 100 mg of progesterone to be administered every evening.

Was not effective in reducing the frequency of vasomotor symptoms in black patients.

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