Protein expression which is a marker for germinal center derivation and is a marker for the prognosis in diffuse large B cell lymphoma treated with conventional chemotherapy.
Expression suggests a favorable outcome in DLBCL.
Is not a prognostic marker in patients with DLCBL treated with CHOP-R but it is a powerful predictor of outcome in patients treated with CHOP alone.
Rituximab improves the outcome in bcl-6- cases but not in bcl-6+ patients.