Antiapoptotic protein that inhibits anticancer drug-induced apoptosis.
A family of proteins that help regulate intrinsic apoptosis and the overexpression is seen in a variety of solid tumors and felt to play a role in tumor cell survival and resistance to chemotherapy.
Frequently overexpressed in small cell lung cancer, and its up regulation has been seen with chemotherapy resistance.
BCL2 (B-cell lymphoma 2), an antiapoptotic molecule strongly expressed in CLL cells, has emerged as another important therapeutic target.
Overexpression associated with drug resistance in various malignancies.
Plays a key role in determining responsiveness to chemotherapy in tumor cells.
Protein overexpression in leukemia, lymphoma, myeloma, lung cancer, melanoma, breast cancer, colorectal cancer and gastric carcinoma.
May be positive in follicular and mantle zone lymphoma.
Confers resistance to chemotherapy in non-Hodgkin’s chemotherapy treatment.