Noncardiac surgery associated with platelet activation, and coronary artery thrombus with myocardial infarction may occur perioperatively.
Perioperative aspirin may prevent major vascular complications by inhibiting thrombus formation.
In randomized trials aspirin prevent MI and major vascular events in patients not undergoing surgery.
High dose aspirin not superior to low dose aspirin in preventing vascular complications.
Low dose aspirin associated with fewer gastric toxic effects.
In a randomized trial of 10,010 patients with cardiovascular risk, undergoing noncardiac surgery with administration of aspirin or placebo before and throughout early postoperative period: aspirin had no effect on the rate of composite death, or no fatal MI, but increased the risk of major bleeding .(POISE-2 Investigators).