Anti-Ro (SS-A)-antibody

Associated with increased neonatal risk for lupus and congenital heart block.

Often positive in primary Sjogren’s syndrome.

Antibodies against SSA/Ro are found in approximately 50% of patients with SS disease (75% of patients with primary Sjögren syndrome and 15% of patients with secondary Sjögren syndrome). 



Anti-Ro is a polyclonal antibody directed against nuclear and nucleolar RNA binding protein of 60KD or cytoplasmic protein of 52KD.


Antibodies against SSA/Ro are present in 50% of patients with SLE and are sometimes found in healthy individuals. 



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