Associated with increased neonatal risk for lupus and congenital heart block.
Often positive in primary Sjogren’s syndrome.
Antibodies against SSA/Ro are found in approximately 50% of patients with SS disease (75% of patients with primary Sjögren syndrome and 15% of patients with secondary Sjögren syndrome).
Anti-Ro is a polyclonal antibody directed against nuclear and nucleolar RNA binding protein of 60KD or cytoplasmic protein of 52KD.
Antibodies against SSA/Ro are present in 50% of patients with SLE and are sometimes found in healthy individuals.