Associated with increases risk of arterial and venous thromboses, fetal loss, thrombocytopenia, superficial thrombophlebitis, cardiac valve disease, livedo reticularis, and migraine headaches.
Share binding affinity for cardiolipin.
Detected by enzyme-linked immunosorbent assays, which are poorly standardized.
Isotypes of IgG, IgM or IgA.
IgG isotype most strongly a with thrombosis.
Some correlation between titers and disease severity.
Eye disease typically inflammatory rather than thrombotic in nature.