Anticardiolipin antibodies

Associated with increases risk of arterial and venous thromboses, fetal loss, thrombocytopenia, superficial thrombophlebitis, cardiac valve disease, livedo reticularis, and migraine headaches.

Share binding affinity for cardiolipin.

Detected by enzyme-linked immunosorbent assays, which are poorly standardized.

Isotypes of IgG, IgM or IgA.

IgG isotype most strongly a with thrombosis.

Some correlation between titers and disease severity.

Eye disease typically inflammatory rather than thrombotic in nature.

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