Anti-cyclic citrullinated peptide antibodies

These antibodies and anti-perinuclear factor and antifilaggrin antibodies target citrulline, a modified form of arginine produced through the action of pepitidyl-arginine-deaminase.

Called anti-cyclic citrullinated peptide antibodies (anti-CCP) test has a sensitivity of 50-70% and a specificity of 95-98% for rheumatoid arthritis.

A meta-analysis reports sensitivity and specificity of the anti-CCP test for rheumatoid arthritis of 67% and 95%, respectively (Nishimura).

Anti-CCP first highly specific biomarker with rheumatoid arthritis.

Has a greater specificity for rheumatoid arthritis.

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