Trade name Olmifon

Oral agent.

US: Not FDA approved,

Bioavailability 80%

Metabolism 75% (liver)

Metabolites Modafinil

Elimination half-life 1 hour (T1/2 is 12–15 hours for modafinil)

Excretion Kidney

A wakefulness-promoting medication to improve alertness, attention, wakefulness, and mood, particularly in the elderly.

It is used to avoid fatigue, such as night workers or others who needed to stay awake and alert for long periods of time. 

It has been used non-medically as a nootropic.

Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in very similar pharmacological effects.

Effects usually are apparent within 45–60 minutes when taken orally.

It is a wakefulness-promoting agent and was used to promote alertness, attention, wakefulness, and mood.

It was particularly used in the elderly.

Relative to adrafinil, modafinil possesses greater specificity in its action.

Modafinil lacks or has a reduced incidence of many of the common side effects of the former including:  stomach pain, skin irritation, anxiety, and elevated liver enzymes with prolonged use.

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