Acid suppressive medication

Prevalence of such agents estimated to be between 40-70% of medical inpatients (Nardino R).

Approximately half of patients prescribed acid suppressive medication during a hospitalization continue such agents after discharge.

Up to 70% of inpatient use of such agents not supported by research.

Associated with increased risk for community acquired pneumonia both in users of proton pump inhibitors and histamine 2 receptor antagonists.

In England a study revealed the highest risk for community acquired pneumonia occurred within the first 2 days of initiation of proton pump inhibitor therapy (Sarkar M).

In a large hospital based study use of proton pump inhibitors was associated with a 30% increased odds of hospital acquired pneumonia (Herzig S).

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