Zieve syndrome

Alcoholic liver disease, hemolysis and hyperlipidemia in the presence of alcohol abuse.

Hemolysis due to alcohol induced deficiency of vitamin E, which reduces polyunsaturated fatty acid levels and causes oxidation of reduced red blood cell glutathione, leading to enzyme instability and hemolysis.

Fatty acid oxidation causes change in cell membrane composition which leads to injury of red blood cells and liver cells.

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