Women’s Health Initiative Dietary Modification Trial

Randomized trial of 48,835 postmenopausal women to a low fat diet which incorporated higher carbohydrates in the form of vegetables, fruits and grains.

The largest long-term randomized trial of a dietary intervention ever conducted.

In the trial women were randomized to a low-fat diet versus a control diet.

Women in the low-fat group successfully reduced dietary fat by 8.2% of calories consumed, lowered their consumption of saturated fat to less than 10% of calories, and reduced dietary cholesterol intake to less than 300 mg/dL.

The above fat restrictions had no effect on improving outcomes during a nine year study.

Through 19.6 year median follow-up, the breast cancer incidence was lower in the intervention group but not statistically significant.

The incidence of ER positive, PR negative breast cancer was significantly reduced in the intervention group.

There was a statistically significant lower  risk of death for breast cancer, by 20%.


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